Biochemistry of tumours

The lines of research that are developed:

• signaling mechanisms in tumours and interactions of soluble factors and tumour / host metabolites
• mechanisms of metabolic reprogramming in tumours, in particular in metastatic melanoma
• role of NAD metabolism and the enzymes that biosynthesize and consume it; in particular the NAMPT enzyme, in tumour progression and drug resistance
•  role of the extracellular NAMPT protein in the regulation of responses in different cell types and soluble marker
• mechanisms of resistance to target therapies and immunotherapy in melanoma

Principle Investigator: Dr.ssa Valentina Audrito

Team: Valentina Audrito

Main external collaborators: Prof.ssa Nadia Raffaelli (Università Politecnica delle Marche); Prof. Mario Mandalà (Università e Azienda Ospedaliera di Perugia); Prof.ssa Daniela Massi, (Università di Firenze); Prof. Vincenzo Calautti, Prof.ssa Silvia Deaglio, Prof. Chiara Riganti, (Università di Torino); Dr.ssa Sara Sdelci (Center for Genomic Regulation CGR, Barcelona, Spain); Prof. David E. Fisher (Massachusetts General Hospital, Harvard Medical School, Boston).

Funding: Italian Association for Cancer Research AIRC-MFAG #26004